Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Atopaxar. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2R known ✓ | P25116 | 16/20 | 1.00 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Atopaxar SCHEMBL1728925 | 1.00 | F2R (1.00) | F2RMEN1ALDH1A1KMT2AL3MBTL1 | |
| Atopaxar SCHEMBL29904776 | 1.00 | F2R (1.00) | F2RMEN1ALDH1A1KMT2AL3MBTL1 | |
| Atopaxar SCHEMBL30175034 | 0.99 | F2R (1.00) | F2RMEN1ALDH1A1KMT2AL3MBTL1 | |
| Atopaxar SCHEMBL1730339 | 0.99 | F2R (1.00) | F2RMEN1ALDH1A1KMT2AL3MBTL1 | |
| Atopaxar SCHEMBL1729065 | 0.98 | F2R (0.98) | F2RMEN1ALDH1A1KMT2AL3MBTL1 | |
| Bromide SCHEMBL1729548 | 0.96 | F2R (0.93) | F2RMEN1ALDH1A1KMT2AL3MBTL1 | |
| Bromide SCHEMBL1730058 | 0.94 | F2R (0.88) | F2RMEN1ALDH1A1KMT2AL3MBTL1 | |
| Bromide SCHEMBL1730235 | 0.93 | F2R (0.87) | F2RGAAMAPTSMN1; SMN2 | |
| SCHEMBL14449152 | 0.93 | F2R (0.87) | F2RGAAMAPTSMN1; SMN2 | |
| Bromide SCHEMBL5493294 | 0.92 | F2R (0.85) | F2RMEN1ALDH1A1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110393718-B | Application and research method of atropa Sha Xiusuan as novel JAK-STAT3 signal pathway inhibitor | 青岛海洋生物医药研究院 | 2022-10-04 | — | — | CN | disclosed |