Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 20/20 | 0.55 |
| ▸ | KDR | P35968 | 3/20 | 0.55 |
| ▸ | INSR | P06213 | 1/20 | 0.47 |
| ▸ | EML4 | Q9HC35 | 3/20 | 0.46 |
| ▸ | SRPK2 | P78362 | 2/20 | 0.46 |
| ▸ | SRPK1 | Q96SB4 | 2/20 | 0.46 |
| ▸ | GAK | O14976 | 1/20 | 0.46 |
| ▸ | ACOX3 | O15254 | 1/20 | 0.46 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.46 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | ESR1 | P03372 | 1/20 | 0.46 |
| ▸ | PGR | P06401 | 1/20 | 0.46 |
| ▸ | RET | P07949 | 1/20 | 0.46 |
| ▸ | ROS1 | P08922 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.46 |
| ▸ | FER | P16591 | 1/20 | 0.46 |
| ▸ | EPHA1 | P21709 | 1/20 | 0.46 |
| ▸ | DRD1 | P21728 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30009875 | 0.90 | ALK (0.53) | ALKKDRINSREML4SRPK2 | |
| SCHEMBL30009083 | 0.87 | ALK (0.44) | ALKKDR | |
| SCHEMBL30009827 | 0.86 | ALK (0.45) | ALKKDRINSREML4SRPK2 | |
| SCHEMBL27087525 | 0.86 | ALK (0.41) | ALKKDRINSREML4SRPK2 | |
| SCHEMBL27087537 | 0.83 | ALK (0.77) | ALKKDRINSREML4SRPK2 | |
| SCHEMBL27087636 | 0.81 | ALK (0.73) | ALKKDRINSREML4SRPK2 | |
| SCHEMBL28960826 | 0.80 | ALK (0.57) | ALKKDRINSREML4SRPK2 | |
| SCHEMBL27087612 | 0.80 | ALK (0.52) | ALKKDREML4SRPK2SRPK1 | |
| SCHEMBL30009789 | 0.79 | ALK (0.40) | ALKKDREML4SRPK2SRPK1 | |
| SCHEMBL20634798 | 0.79 | ALK (0.74) | ALKKDRINSREML4SRPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022237813-A1 | COMPOUND HAVING ALK INHIBITORY ACTIVITY, PREPARATION METHOD THEREFOR AND USE THEREOF | 盛世泰科生物医药技术(苏州)有限公司 | 2022-11-17 | — | — | WO | disclosed |