Sugi Predict

Sugi Predict / Compounds / SCHEMBL30009856

SCHEMBL30009856

SCHEMBL30009856

CCOC(=O)Cc1ccc(NC(=O)OC(C)C)cc1OCc1cc(-c2cccc(CN)c2)c2occc2c1

nearest known ligand 0.55

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ CFD P00746 16/20 0.55
▸ PLG P00747 1/20 0.37
▸ PLAU P00749 1/20 0.37
▸ F11 P03951 1/20 0.37
▸ KLKB1 P03952 1/20 0.37
▸ F7 P08709 1/20 0.37
▸ TPSB2 P20231 1/20 0.37
▸ KDM4E B2RXH2 1/20 0.36
▸ BTK Q06187 1/20 0.35
▸ KCNB1 Q14721 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23217641 1.00 CFD (0.55) CFDPLGPLAUF11KLKB1
SCHEMBL30010028 0.93 CFD (0.58) CFDPLGPLAUF11KLKB1
SCHEMBL23217868 0.93 CFD (0.58) CFDPLGPLAUF11KLKB1
SCHEMBL23217652 0.92 CFD (0.57) CFDPLGPLAUF11KLKB1
SCHEMBL30010524 0.92 CFD (0.57) CFDPLGPLAUF11KLKB1
SCHEMBL23217656 0.91 CFD (0.63) CFDPLGPLAUF11KLKB1
SCHEMBL30009982 0.91 CFD (0.63) CFDPLGPLAUF11KLKB1
SCHEMBL21438087 0.90 CFD (0.59) CFDPLGPLAUF11KLKB1
SCHEMBL23217745 0.90 CFD (0.54) CFDPLGPLAUF11KLKB1
SCHEMBL30010530 0.90 CFD (0.54) CFDPLGPLAUF11KLKB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4041717-A1 ORAL COMPLEMENT FACTOR D INHIBITORS Biocryst Pharmaceuticals, Inc. (US) 2022-08-17 — — EP disclosed