SCHEMBL30009939

SCHEMBL30009939

C[C@H](Nc1nc(Nc2cc(C3CC3)n[nH]2)c(Cl)c(NC(CO)CO)n1)c1ccc(F)cc1

nearest known ligand 0.74

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
NTRK1 P04629 19/20 0.74
GRK6 P43250 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3337098 1.00 NTRK1 (0.74) NTRK1GRK6
SCHEMBL4065664 1.00 NTRK1 (0.74) NTRK1GRK6
SCHEMBL4068043 0.89 NTRK1 (0.75) NTRK1GRK6
SCHEMBL4076742 0.88 NTRK1 (0.76) NTRK1GRK6
SCHEMBL4073738 0.87 NTRK1 (0.56) NTRK1GRK6
SCHEMBL4069542 0.87 NTRK1 (0.64) NTRK1GRK6
SCHEMBL4156670 0.85 NTRK1 (1.00) NTRK1
SCHEMBL4074781 0.84 NTRK1 (0.65) NTRK1GRK6
SCHEMBL4065458 0.84 NTRK1 (0.61) NTRK1GRK6
SCHEMBL4073723 0.84 NTRK1 (0.53) NTRK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4041259-A1 FEEDER-BASED AND FEEDER-FREE STEM CELL CULTURE SYSTEMS FOR STRATIFIED EPITHELIAL STEM CELLS, AND USES RELATED THERETO University of Houston System (US) 2022-08-17 EP disclosed