Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 16/20 | 0.65 |
| ▸ | GRK6 | P43250 | 4/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4076742 | 0.93 | NTRK1 (0.76) | NTRK1GRK6 | |
| SCHEMBL4069542 | 0.92 | NTRK1 (0.64) | NTRK1GRK6AURKA | |
| SCHEMBL4072194 | 0.90 | NTRK1 (0.57) | NTRK1 | |
| SCHEMBL4065458 | 0.89 | NTRK1 (0.61) | NTRK1GRK6AURKA | |
| SCHEMBL4068043 | 0.87 | NTRK1 (0.75) | NTRK1GRK6 | |
| SCHEMBL4156688 | 0.86 | NTRK1 (0.87) | NTRK1 | |
| SCHEMBL4068018 | 0.84 | NTRK1 (0.64) | NTRK1 | |
| SCHEMBL4068935 | 0.84 | NTRK1 (0.64) | NTRK1 | |
| SCHEMBL4071059 | 0.84 | NTRK1 (0.64) | NTRK1 | |
| SCHEMBL3337098 | 0.84 | NTRK1 (0.74) | NTRK1GRK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1686999-B1 | PYRAZOLE DERIVATIVES AS INHIBITORS OF RECEPTOR TYROSINE KINASES | ASTRAZENECA AB (SE) | 2009-07-01 | — | — | EP | disclosed |