Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 9/20 | 0.51 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.51 |
| ▸ | PROKR1 | Q8TCW9 | 2/20 | 0.49 |
| ▸ | PDE5A | O76074 | 3/20 | 0.48 |
| ▸ | PDE4A | P27815 | 1/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | PDE1A | P54750 | 1/20 | 0.43 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.43 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.43 |
| ▸ | PNP | P00491 | 1/20 | 0.43 |
| ▸ | PROKR2 | Q8NFJ6 | 1/20 | 0.42 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23392733 | 1.00 | ADORA3 (0.51) | ADORA3ADORA1PROKR1PDE5APDE4A | |
| SCHEMBL26926620 | 0.85 | MAPT (0.50) | ADORA3ADORA1PDE5APDE4APDE4B | |
| SCHEMBL30012159 | 0.83 | ADORA3 (0.59) | ADORA3ADORA1PROKR1PDE5APDE4A | |
| SCHEMBL23392748 | 0.83 | ADORA3 (0.59) | ADORA3ADORA1PROKR1PDE5APDE4A | |
| SCHEMBL30012989 | 0.83 | ADORA3 (0.55) | ADORA3ADORA1PROKR1NPSR1TLR7 | |
| SCHEMBL23202134 | 0.83 | ADORA3 (0.55) | ADORA3ADORA1PROKR1NPSR1TLR7 | |
| SCHEMBL23202394 | 0.82 | PDE5A (0.68) | ADORA3PROKR1PDE5APDE4APDE4B | |
| SCHEMBL30012671 | 0.82 | PDE5A (0.68) | ADORA3PROKR1PDE5APDE4APDE4B | |
| SCHEMBL5606379 | 0.77 | HSP90AA1 (0.56) | TLR7 | |
| SCHEMBL23392898 | 0.77 | ADORA3 (0.57) | ADORA3ADORA1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115427063-A | TLR7 agonists | 普利缪尼治疗学股份有限公司 | 2022-12-02 | — | — | CN | disclosed |
| EP-4065155-A1 | TLR7 AGONISTS | Primmune Therapeutics, Inc. (US) | 2022-10-05 | — | — | EP | disclosed |