Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 11/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 4/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.36 |
| ▸ | FECH | P22830 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | CLK1 | P49759 | 1/20 | 0.36 |
| ▸ | GSK3A | P49840 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | MELK | Q14680 | 1/20 | 0.36 |
| ▸ | MYLK3 | Q32MK0 | 1/20 | 0.36 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.36 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30012579 | 0.92 | MTOR (0.39) | MTORPDE3BPDE3AFLT3SYK | |
| SCHEMBL30012169 | 0.91 | MTOR (0.41) | MTORPDE3BPDE3AFLT3SYK | |
| SCHEMBL30011050 | 0.90 | MTOR (0.41) | MTORPDE3BPDE3AFLT3SYK | |
| SCHEMBL30011461 | 0.81 | ATM (0.42) | MTORPDE3BPDE3ASYKPIK3CD | |
| SCHEMBL30012532 | 0.80 | ATM (0.41) | MTORSYKPIK3CAMELKMAPK14 | |
| SCHEMBL30839640 | 0.80 | ATM (0.41) | MTORSYKPIK3CAMELKMAPK14 | |
| SCHEMBL30013129 | 0.77 | ATM (0.47) | MTORPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL30012567 | 0.75 | MTOR (0.45) | MTORPIK3CDCSNK2A2FECHPIK3CA | |
| SCHEMBL29217578 | 0.75 | MTOR (0.45) | MTORPIK3CDCSNK2A2FECHPIK3CA | |
| SCHEMBL22891687 | 0.73 | IRAK4 (0.37) | MTORFLT3PIK3CAMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220259211-A1 | SUBSTITUTED PYRAZOLOQUINAZOLINONE COMPOUNDS AND APPLICATION THEREOF | Impact Therapeutics (Shanghai), Inc (CN) | 2022-08-18 | — | — | US | claimed |
| CN-114026097-B | Substituted pyrazoloquinazolinone compounds and uses thereof | 上海瑛派药业有限公司 | 2024-02-23 | — | — | CN | disclosed |
| US-20220259211-A1 | SUBSTITUTED PYRAZOLOQUINAZOLINONE COMPOUNDS AND APPLICATION THEREOF | Impact Therapeutics (Shanghai), Inc (CN) | 2022-08-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220259211-A1 | SUBSTITUTED PYRAZOLOQUINAZOLINONE COMPOUNDS AND APPLICATION THEREOF | CHEK1, CHEK2, ATM | MTOR 283/4885PDE3B 1262/4885PDE3A 1107/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.