Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.33 |
| ▸ | HTR3A | P46098 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 4/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
| ▸ | CTSL | P07711 | 1/20 | 0.31 |
| ▸ | CTSB | P07858 | 1/20 | 0.31 |
| ▸ | CTSK | P43235 | 1/20 | 0.31 |
| ▸ | EP300 | Q09472 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL470809 | 0.85 | TDP1 (0.40) | TDP1SLC6A2SLC6A4HTR3AKCNH2 | |
| SCHEMBL797411 | 0.81 | TDP1 (0.38) | TDP1SLC6A2SLC6A4HTR3AKCNH2 | |
| SCHEMBL796522 | 0.81 | SLC6A2 (0.37) | TDP1SLC6A2SLC6A4HTR3AKCNH2 | |
| Hydrochloric Acid SCHEMBL17220300 | 0.79 | TDP1 (0.41) | TDP1SLC6A2SLC6A4HTR3AKCNH2 | |
| Hydrochloric Acid SCHEMBL17220374 | 0.79 | TDP1 (0.39) | TDP1SLC6A2SLC6A4HTR3AKCNH2 | |
| Hydrochloric Acid SCHEMBL7491956 | 0.78 | CTSL (0.43) | TDP1SLC6A2SLC6A4HTR3AKCNH2 | |
| SCHEMBL4104818 | 0.77 | CTSL (0.41) | TDP1SLC6A2SLC6A4HTR3AKCNH2 | |
| SCHEMBL19025161 | 0.77 | CTSL (0.46) | TDP1SLC6A2SLC6A4HTR3AKCNH2 | |
| SCHEMBL13747906 | 0.77 | TDP1 (0.38) | TDP1SLC6A2SLC6A4HTR3AKCNH2 | |
| SCHEMBL8193734 | 0.76 | TDP1 (0.35) | TDP1SLC6A2SLC6A4HTR3AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022223034-A1 | SOS1 DEGRADATION AGENT AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | 上海领泰生物医药科技有限公司 | 2022-10-27 | — | — | WO | disclosed |
| WO-2022223033-A1 | SOS1 DEGRADING AGENT AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | 上海领泰生物医药科技有限公司 | 2022-10-27 | — | — | WO | disclosed |
| WO-2022223039-A1 | SOS1 DEGRADER, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | 上海领泰生物医药科技有限公司 | 2022-10-27 | — | — | WO | disclosed |