Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 4/20 | 0.32 |
| ▸ | RAB9A | P51151 | 4/20 | 0.32 |
| ▸ | GCK | P35557 | 4/20 | 0.31 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.31 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.31 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2997075 | 0.90 | HPGDS (0.45) | HPGDSGRM5NPC1RAB9AGCK | |
| SCHEMBL3008721 | 0.89 | HPGDS (0.45) | HPGDSGRM5NPC1RAB9AGCK | |
| SCHEMBL2994480 | 0.88 | HPGDS (0.43) | HPGDSGRM5NPC1RAB9AGCK | |
| SCHEMBL2994602 | 0.87 | GRM5 (0.39) | HPGDSGRM5NPC1RAB9AGCK | |
| SCHEMBL3003372 | 0.86 | GRM5 (0.38) | HPGDSGRM5NPC1RAB9AGCK | |
| SCHEMBL3003127 | 0.85 | GRM5 (0.42) | HPGDSGRM5NPC1RAB9AGCK | |
| SCHEMBL2994085 | 0.85 | GRM5 (0.38) | HPGDSGRM5NPC1RAB9AGCK | |
| SCHEMBL3008822 | 0.85 | GRM5 (0.39) | HPGDSGRM5NPC1RAB9AGCK | |
| Hydrochloric Acid SCHEMBL3002290 | 0.85 | GRM5 (0.41) | HPGDSGRM5NPC1RAB9AGCK | |
| SCHEMBL3003089 | 0.84 | GCK (0.39) | HPGDSGRM5NPC1RAB9AGCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100190980-A1 | PYRAZINAMIDE COMPOUND | TAISHO PHARMACEUTICAL CO., LTD (JP) | 2010-07-29 | — | — | US | claimed |
| EP-2157090-A1 | PYRAZINAMIDE COMPOUND | Taisho Pharmaceutical Co. Ltd. (JP) | 2010-02-24 | — | — | EP | claimed |
| US-20100190980-A1 | PYRAZINAMIDE COMPOUND | TAISHO PHARMACEUTICAL CO., LTD (JP) | 2010-07-29 | — | — | US | disclosed |
| EP-2157090-A1 | PYRAZINAMIDE COMPOUND | Taisho Pharmaceutical Co. Ltd. (JP) | 2010-02-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100190980-A1 | PYRAZINAMIDE COMPOUND | KAT8, GK, KCNJ8 | HPGDS 4392/4885GRM5 1751/4885NPC1 2169/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.