Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 8/20 | 0.46 |
| ▸ | KDM6B | O15054 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KDM4A | O75164 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | POLQ | O75417 | 2/20 | 0.45 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KDM5A | P29375 | 1/20 | 0.40 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.40 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29573953 | 0.88 | SLC22A12 (0.53) | KDM4CALDH1A1KDM4ETDP1POLQ | |
| SCHEMBL22717569 | 0.88 | SLC22A12 (0.53) | KDM4CALDH1A1KDM4ETDP1POLQ | |
| SCHEMBL22731931 | 0.87 | GPBAR1 (0.43) | ALDH1A1KDM4ETDP1MEN1KMT2A | |
| SCHEMBL30578227 | 0.84 | KDM4C (0.53) | KDM4CKDM6BALDH1A1KDM4EMAPT | |
| SCHEMBL115719 | 0.84 | KDM4C (0.53) | KDM4CKDM6BALDH1A1KDM4EMAPT | |
| Hydrochloric Acid SCHEMBL459608 | 0.83 | KDM4C (0.52) | KDM4CKDM6BALDH1A1KDM4EMAPT | |
| SCHEMBL25309598 | 0.83 | POLQ (0.61) | KDM4CPOLQGPBAR1KDM5AKDM5B | |
| SCHEMBL31660849 | 0.83 | POLQ (0.61) | KDM4CPOLQGPBAR1KDM5AKDM5B | |
| SCHEMBL27598697 | 0.82 | MAPT (0.49) | KDM4CKDM6BALDH1A1KDM4EMAPT | |
| SCHEMBL24770954 | 0.82 | KDM4C (0.46) | KDM4CKDM6BALDH1A1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4352055-A1 | O-LINKED THIADIAZOLYL COMPOUNDS AS DNA POLYMERASE THETA INHIBITORS | Ideaya Biosciences, Inc. (US) | 2024-04-17 | — | — | EP | disclosed |
| WO-2022259204-A1 | O-LINKED THIADIAZOLYL COMPOUNDS AS DNA POLYMERASE THETA INHIBITORS | IDEAYA BIOSCIENCES, INC. (US) | 2022-12-15 | — | — | WO | disclosed |