Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 9/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | ZAP70 | P43403 | 4/20 | 0.35 |
| ▸ | PDE5A | O76074 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.34 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.34 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30018774 | 0.89 | ADRB2 (0.42) | PDE10AZAP70 | |
| SCHEMBL30019339 | 0.89 | PDE10A (0.44) | PDE10AZAP70MAP4K1 | |
| SCHEMBL30019410 | 0.84 | MAP4K1 (0.47) | PDE10AZAP70MAP4K1 | |
| SCHEMBL30017982 | 0.84 | PDE10A (0.44) | PDE10AZAP70MAP4K1 | |
| SCHEMBL30019303 | 0.84 | PDE10A (0.46) | PDE10APDE1BMAP4K1 | |
| SCHEMBL30018153 | 0.83 | PDE10A (0.45) | PDE10ACNR2ZAP70MAP4K1 | |
| SCHEMBL30018028 | 0.83 | PDE10A (0.47) | PDE10AZAP70MAP4K1 | |
| SCHEMBL30017077 | 0.82 | MCHR1 (0.44) | PDE10A | |
| SCHEMBL30018331 | 0.79 | ADRB2 (0.43) | PDE3ALMNATSHR | |
| SCHEMBL31217382 | 0.79 | PDE3B (0.54) | PDE10ACNR2PDE5APDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022208382-A1 | NOVEL DIALKOXYNAPHTHO[2,3-C]FURAN-1(3H)-ONE DERIVATIVES AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING RESPIRATORY DISEASE OR SARS-COV-2 INFECTION DISEASE, COMPRISING SAME | 동화약품주식회사 | 2022-10-06 | — | — | WO | disclosed |