Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT6 | P42226 | 6/20 | 0.62 |
| ▸ | CDK4 | P11802 | 10/20 | 0.61 |
| ▸ | AURKA | O14965 | 6/20 | 0.61 |
| ▸ | CDK1 | P06493 | 2/20 | 0.61 |
| ▸ | INSR | P06213 | 1/20 | 0.61 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.61 |
| ▸ | SRC | P12931 | 1/20 | 0.61 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.61 |
| ▸ | FLT1 | P17948 | 1/20 | 0.61 |
| ▸ | FLT4 | P35916 | 1/20 | 0.61 |
| ▸ | KDR | P35968 | 1/20 | 0.61 |
| ▸ | CDK7 | P50613 | 1/20 | 0.61 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.61 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.58 |
| ▸ | CCND1 | P24385 | 4/20 | 0.56 |
| ▸ | CCND2 | P30279 | 4/20 | 0.56 |
| ▸ | CCND3 | P30281 | 4/20 | 0.56 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.55 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.55 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30019765 | 0.90 | JAK2 (0.55) | STAT6CDK4AURKACDK1INSR | |
| SCHEMBL30017942 | 0.87 | BTK (0.57) | STAT6ABL1BTK | |
| SCHEMBL30017946 | 0.86 | TNK2 (0.63) | STAT6CDK4AURKACDK1INSR | |
| SCHEMBL30019218 | 0.86 | TTK (0.61) | CDK4INSRSRCCCND1 | |
| SCHEMBL30018989 | 0.84 | CDK4 (0.56) | CDK4AURKACDK1INSRPDGFRB | |
| SCHEMBL30019432 | 0.83 | TNK2 (0.57) | STAT6SRC | |
| SCHEMBL30017933 | 0.83 | TNK2 (0.55) | STAT6CDK4AURKACDK1INSR | |
| SCHEMBL30019959 | 0.82 | JAK1 (0.49) | STAT6CDK4AURKA | |
| SCHEMBL27844369 | 0.82 | STAT6 (0.69) | STAT6CDK4AURKACDK1INSR | |
| SCHEMBL15163242 | 0.80 | STAT6 (0.67) | STAT6CDK4AURKACDK1INSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022226290-A1 | 2-PHENYLAMINO PYRROLOPYRIMIDINES AS ACK1 INHIBITORS | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2022-10-27 | — | — | WO | disclosed |