Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 8/20 | 0.61 |
| ▸ | SRC | P12931 | 2/20 | 0.54 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.54 |
| ▸ | JAK2 | O60674 | 2/20 | 0.53 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.53 |
| ▸ | BRD4 | O60885 | 1/20 | 0.53 |
| ▸ | INSR | P06213 | 1/20 | 0.53 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.51 |
| ▸ | EGFR | P00533 | 5/20 | 0.51 |
| ▸ | CDK4 | P11802 | 1/20 | 0.50 |
| ▸ | CCND1 | P24385 | 1/20 | 0.50 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.50 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.50 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30017933 | 0.91 | TNK2 (0.55) | TTKSRCTNK2JAK2ALK | |
| SCHEMBL30020145 | 0.87 | TNK2 (0.68) | TTKSRCTNK2JAK2ALK | |
| SCHEMBL30019954 | 0.86 | TNK2 (0.48) | TTKSRCTNK2JAK2ALK | |
| SCHEMBL30019212 | 0.86 | STAT6 (0.62) | SRCINSRCDK4CCND1 | |
| SCHEMBL30019765 | 0.84 | JAK2 (0.55) | SRCJAK2BRD4INSRCDK4 | |
| SCHEMBL30019414 | 0.82 | STAT6 (0.44) | TTKSRCTNK2JAK2ALK | |
| SCHEMBL29714294 | 0.80 | TTK (0.62) | TTKEGFRCDK4CCND1CDK6 | |
| SCHEMBL27196749 | 0.80 | TTK (0.62) | TTKEGFRCDK4CCND1CDK6 | |
| SCHEMBL30019426 | 0.80 | TNK2 (0.67) | TTKSRCTNK2JAK2ALK | |
| SCHEMBL30019432 | 0.79 | TNK2 (0.57) | SRCTNK2JAK2BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022226290-A1 | 2-PHENYLAMINO PYRROLOPYRIMIDINES AS ACK1 INHIBITORS | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2022-10-27 | — | — | WO | disclosed |