Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNK2 | Q07912 | 7/20 | 0.68 |
| ▸ | SRC | P12931 | 4/20 | 0.68 |
| ▸ | JAK2 | O60674 | 2/20 | 0.66 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.66 |
| ▸ | TTK | P33981 | 8/20 | 0.57 |
| ▸ | BRD4 | O60885 | 1/20 | 0.52 |
| ▸ | CDK4 | P11802 | 1/20 | 0.51 |
| ▸ | CCND1 | P24385 | 1/20 | 0.51 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30019426 | 0.92 | TNK2 (0.67) | TNK2SRCJAK2ALKTTK | |
| SCHEMBL30019218 | 0.87 | TTK (0.61) | TNK2SRCJAK2ALKTTK | |
| SCHEMBL30019375 | 0.87 | TNK2 (0.53) | TNK2SRCJAK2ALK | |
| SCHEMBL30019409 | 0.87 | TNK2 (0.53) | TNK2SRCJAK2ALK | |
| SCHEMBL30019421 | 0.86 | TNK2 (0.63) | TNK2SRCJAK2ALKTTK | |
| SCHEMBL30017946 | 0.86 | TNK2 (0.63) | TNK2SRCJAK2ALKCDK4 | |
| SCHEMBL30019519 | 0.84 | TNK2 (0.55) | TNK2SRCJAK2ALKBRD4 | |
| SCHEMBL30017933 | 0.80 | TNK2 (0.55) | TNK2SRCJAK2ALKTTK | |
| SCHEMBL30020151 | 0.80 | TNK2 (0.70) | TNK2SRC | |
| SCHEMBL18488284 | 0.80 | TNK2 (1.00) | TNK2SRCJAK2ALKEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022226290-A1 | 2-PHENYLAMINO PYRROLOPYRIMIDINES AS ACK1 INHIBITORS | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2022-10-27 | — | — | WO | disclosed |