Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.49 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CDC25A | P30304 | 2/20 | 0.35 |
| ▸ | CDC25C | P30307 | 2/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | GABRP | O00591 | 2/20 | 0.35 |
| ▸ | GABRD | O14764 | 2/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.35 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.35 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23537467 | 1.00 | PIM1 (0.49) | PIM1PIM3ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL23537407 | 0.83 | ALDH1A1 (0.44) | PIM1PIM3ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL29824591 | 0.83 | ALDH1A1 (0.44) | PIM1PIM3ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL23537530 | 0.79 | ALDH1A1 (0.47) | PIM1PIM3ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL28798906 | 0.79 | PIM1 (0.59) | PIM1PIM3ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL23537551 | 0.76 | ALDH1A1 (0.47) | PIM1PIM3ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL30023090 | 0.76 | ALDH1A1 (0.47) | PIM1PIM3ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL12789436 | 0.73 | ALDH1A1 (0.46) | PIM1PIM3ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL28871672 | 0.72 | NQO1 (0.32) | ALDH1A1CDC25ACDC25CGABRPGABRD | |
| SCHEMBL23537613 | 0.70 | PARP1 (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4149945-A1 | SUBSTITUTED TRICYCLIC AMIDES, ANALOGUES THEREOF, AND METHODS USING SAME | Arbutus Biopharma Corporation (CA) | 2023-03-22 | — | — | EP | disclosed |
| EP-4076648-A1 | SUBSTITUTED BICYCLIC AND TRICYCLIC UREAS AND AMIDES, ANALOGUES THEREOF, AND METHODS USING SAME | Arbutus Biopharma Corporation (CA) | 2022-10-26 | — | — | EP | disclosed |