Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2061643 | 0.79 | TNF (0.50) | KDM4EPOLBHTTALDH1A1MAPT | |
| SCHEMBL12160564 | 0.78 | KDM4E (0.44) | KDM4EPOLBALDH1A1MAPTTDP1 | |
| SCHEMBL31033159 | 0.78 | KDM4E (0.48) | KDM4EPOLBALDH1A1MAPTTDP1 | |
| SCHEMBL4793671 | 0.76 | BRD4 (0.41) | KDM4EPOLBALDH1A1MAPTMEN1 | |
| SCHEMBL24026589 | 0.76 | KDM4E (0.41) | KDM4EPOLBALDH1A1MAPTTDP1 | |
| SCHEMBL30058552 | 0.76 | POLB (0.49) | KDM4EPOLBALDH1A1MAPTMEN1 | |
| SCHEMBL23553038 | 0.76 | POLB (0.49) | KDM4EPOLBALDH1A1MAPTMEN1 | |
| SCHEMBL2060642 | 0.75 | CYP1A2 (0.41) | HTTALDH1A1MAPTTDP1ACHE | |
| SCHEMBL14437898 | 0.74 | PARP1 (0.42) | KDM4EPOLBALDH1A1MAPTMEN1 | |
| Lithium Ion SCHEMBL23534386 | 0.74 | TNF (0.36) | KDM4EPOLBHTTALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076459-A1 | PRMT5 INHIBITORS | Merck Sharp & Dohme LLC (US) | 2022-10-26 | — | — | EP | claimed |