Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATF4 | P18848 | 9/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.58 |
| ▸ | MEN1 | O00255 | 4/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | NPY1R | P25929 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19569418 | 1.00 | ATF4 (0.74) | ATF4KMT2AMEN1POLBMAPT | |
| SCHEMBL19569430 | 0.89 | ATF4 (0.80) | ATF4ALDH1A1LMNAGAA | |
| SCHEMBL19569416 | 0.87 | ATF4 (0.86) | ATF4KMT2AMEN1POLBMAPT | |
| SCHEMBL19577396 | 0.87 | PPARD (0.56) | ATF4KMT2AMEN1POLBMAPT | |
| SCHEMBL23149137 | 0.86 | ATF4 (0.89) | ATF4KMT2A | |
| SCHEMBL20974142 | 0.86 | ATF4 (1.00) | ATF4KMT2AMEN1ALDH1A1 | |
| SCHEMBL19569438 | 0.86 | ATF4 (0.74) | ATF4ALDH1A1 | |
| SCHEMBL20974145 | 0.85 | ATF4 (0.54) | ATF4KMT2AMEN1POLBTDP1 | |
| SCHEMBL19569413 | 0.84 | ATF4 (0.76) | ATF4POLBMAPTALDH1A1LMNA | |
| SCHEMBL19556192 | 0.83 | ATF4 (0.89) | ATF4KMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115947681-A | Modulators of integrated stress pathways | 卡里科生命科学有限责任公司 | 2023-04-11 | — | — | CN | disclosed |
| CN-109641844-B | Modulators of integrated stress pathways | 卡里科生命科学有限责任公司 | 2022-11-01 | — | — | CN | disclosed |