Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATF4 | P18848 | 17/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SENP2 | Q9HC62 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20973765 | 1.00 | ATF4 (0.62) | ATF4POLBSENP2ALDH1A1 | |
| SCHEMBL19569517 | 0.92 | ATF4 (0.52) | ATF4POLBSENP2ALDH1A1 | |
| SCHEMBL19555849 | 0.88 | ATF4 (0.60) | ATF4POLBSENP2 | |
| SCHEMBL19555496 | 0.86 | ATF4 (0.47) | ATF4 | |
| SCHEMBL30024698 | 0.86 | ATF4 (0.79) | ATF4 | |
| SCHEMBL19569507 | 0.86 | ATF4 (0.79) | ATF4 | |
| SCHEMBL30026071 | 0.86 | ATF4 (0.64) | ATF4 | |
| SCHEMBL20973815 | 0.86 | ATF4 (0.64) | ATF4 | |
| SCHEMBL19569361 | 0.85 | ATF4 (0.69) | ATF4ALDH1A1 | |
| SCHEMBL30961496 | 0.85 | ATF4 (0.69) | ATF4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3704094-B1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC (US) | 2026-03-11 | — | — | EP | disclosed |
| CN-115947681-A | Modulators of integrated stress pathways | 卡里科生命科学有限责任公司 | 2023-04-11 | — | — | CN | disclosed |
| CN-109641844-B | Modulators of integrated stress pathways | 卡里科生命科学有限责任公司 | 2022-11-01 | — | — | CN | disclosed |