Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 14/20 | 0.53 |
| ▸ | CRBN | Q96SW2 | 14/20 | 0.53 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.38 |
| ▸ | PRKDC | P78527 | 6/20 | 0.38 |
| ▸ | MTOR | P42345 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23540937 | 1.00 | DDB1 (0.53) | DDB1CRBNPIK3CAPRKDCMTOR | |
| SCHEMBL23541172 | 0.90 | DDB1 (0.58) | DDB1CRBN | |
| SCHEMBL23540563 | 0.89 | DDB1 (0.58) | DDB1CRBNPIK3CAPRKDCMTOR | |
| SCHEMBL30026446 | 0.89 | DDB1 (0.58) | DDB1CRBNPIK3CAPRKDCMTOR | |
| SCHEMBL23842106 | 0.86 | DDB1 (0.64) | DDB1CRBN | |
| SCHEMBL23540958 | 0.80 | CRBN (0.53) | DDB1CRBNPIK3CAPRKDC | |
| SCHEMBL23541014 | 0.80 | DDB1 (0.53) | DDB1CRBNPIK3CAPRKDCMTOR | |
| SCHEMBL23540624 | 0.79 | DDB1 (0.49) | DDB1CRBNPRKDCMTOR | |
| SCHEMBL22526656 | 0.79 | CRBN (0.62) | DDB1CRBN | |
| SCHEMBL29651793 | 0.79 | CRBN (0.62) | DDB1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4077319-A1 | PROTEIN TYROSINE PHOSPHATASE DEGRADERS AND METHODS OF USE THEREOF | Calico Life Sciences LLC (US) | 2022-10-26 | — | — | EP | disclosed |