Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | USP2 | O75604 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | PDE5A | O76074 | 4/20 | 0.33 |
| ▸ | PDE6D | O43924 | 1/20 | 0.33 |
| ▸ | PDE6A | P16499 | 1/20 | 0.33 |
| ▸ | PDE6G | P18545 | 1/20 | 0.33 |
| ▸ | PDE6B | P35913 | 1/20 | 0.33 |
| ▸ | PDE6C | P51160 | 1/20 | 0.33 |
| ▸ | PDE6H | Q13956 | 1/20 | 0.33 |
| ▸ | VSIR | Q9H7M9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28896633 | 1.00 | MAPT (0.35) | MAPTKDM4ETSHRSMN1; SMN2CCNT1 | |
| SCHEMBL28896305 | 0.88 | CCNT1 (0.37) | MAPTKDM4ETSHRSMN1; SMN2CCNT1 | |
| SCHEMBL30028600 | 0.88 | CCNT1 (0.37) | MAPTKDM4ETSHRSMN1; SMN2CCNT1 | |
| SCHEMBL28896630 | 0.84 | TSHR (0.35) | MAPTTSHRSMN1; SMN2LMNAUSP2 | |
| SCHEMBL28896655 | 0.80 | MDM2 (0.32) | MAPTKDM4ETSHRSMN1; SMN2 | |
| SCHEMBL30029534 | 0.80 | MDM2 (0.32) | MAPTKDM4ETSHRSMN1; SMN2 | |
| SCHEMBL28896304 | 0.80 | TSHR (0.35) | MAPTTSHRSMN1; SMN2LMNAUSP2 | |
| SCHEMBL28896259 | 0.72 | TSHR (0.43) | MAPTKDM4ETSHRSMN1; SMN2LMNA | |
| SCHEMBL30028198 | 0.72 | TSHR (0.43) | MAPTKDM4ETSHRSMN1; SMN2LMNA | |
| SCHEMBL28896549 | 0.68 | KDM4E (0.40) | MAPTKDM4ELMNAALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115403584-A | 2-thio-2, 3-dihydropyrimidine-4-one derivative, pharmaceutical composition, preparation method and application thereof | 长春金赛药业有限责任公司 | 2022-11-29 | — | — | CN | disclosed |