Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.34 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.34 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30028198 | 1.00 | TSHR (0.43) | TSHRSMN1; SMN2L3MBTL1ALOX15LMNA | |
| SCHEMBL31603759 | 0.81 | TSHR (0.35) | TSHRSMN1; SMN2L3MBTL1ALOX15MAPT | |
| SCHEMBL27413370 | 0.78 | L3MBTL1 (0.43) | L3MBTL1MAPTNPSR1RECQLKDM4E | |
| SCHEMBL28896369 | 0.77 | TSHR (0.39) | TSHRSMN1; SMN2LMNAMAPTNPSR1 | |
| SCHEMBL28896249 | 0.77 | SMN1; SMN2 (0.40) | TSHRSMN1; SMN2ALOX15LMNATP53 | |
| SCHEMBL30601268 | 0.76 | LMNA (0.53) | ALOX15LMNATP53MAPTNPSR1 | |
| SCHEMBL30601264 | 0.76 | LMNA (0.53) | ALOX15LMNATP53MAPTNPSR1 | |
| SCHEMBL28896561 | 0.76 | TSHR (0.40) | TSHRSMN1; SMN2LMNATP53MAPT | |
| SCHEMBL28896568 | 0.76 | PDE5A (0.41) | TSHRSMN1; SMN2LMNAMAPTNPSR1 | |
| SCHEMBL28896306 | 0.75 | SMN1; SMN2 (0.39) | TSHRSMN1; SMN2L3MBTL1ALOX15LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115403584-B | 2-thio-2, 3-dihydropyrimidine-4-one derivatives, pharmaceutical compositions, preparation methods and applications thereof | 长春金赛药业有限责任公司 | 2024-04-02 | — | — | CN | disclosed |
| CN-115403584-A | 2-thio-2, 3-dihydropyrimidine-4-one derivative, pharmaceutical composition, preparation method and application thereof | 长春金赛药业有限责任公司 | 2022-11-29 | — | — | CN | disclosed |