Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 2/20 | 0.53 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.53 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.53 |
| ▸ | CCND1 | P24385 | 17/20 | 0.51 |
| ▸ | CDK2 | P24941 | 15/20 | 0.51 |
| ▸ | CDK4 | P11802 | 13/20 | 0.51 |
| ▸ | CCNE1 | P24864 | 13/20 | 0.51 |
| ▸ | CCND2 | P30279 | 10/20 | 0.51 |
| ▸ | CCND3 | P30281 | 10/20 | 0.51 |
| ▸ | CCNA2 | P20248 | 7/20 | 0.51 |
| ▸ | CCNA1 | P78396 | 6/20 | 0.51 |
| ▸ | CCNE2 | O96020 | 5/20 | 0.51 |
| ▸ | CCNB2 | O95067 | 3/20 | 0.51 |
| ▸ | CDK1 | P06493 | 3/20 | 0.51 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.51 |
| ▸ | CCNB3 | Q8WWL7 | 3/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.47 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.47 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.47 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5268314 | 0.77 | CDK4 (0.81) | CCND1CDK2CDK4CCNE1CCND2 | |
| SCHEMBL20991960 | 0.76 | CDK2 (0.57) | CCND1CDK2CDK4CCNE1CCND2 | |
| SCHEMBL20992081 | 0.76 | CDK2 (0.57) | CCND1CDK2CDK4CCNE1CCND2 | |
| SCHEMBL26160613 | 0.75 | PRKDC (0.60) | — | |
| SCHEMBL26160595 | 0.75 | JAK2 (0.57) | — | |
| SCHEMBL5263689 | 0.73 | CDK4 (0.89) | CCND1CDK2CDK4CCNE1CCND2 | |
| SCHEMBL31637530 | 0.72 | CCND1 (0.49) | MAPK8MAPK9MAPK10CCND1CDK2 | |
| SCHEMBL4828611 | 0.72 | CCND1 (0.49) | MAPK8MAPK9MAPK10CCND1CDK2 | |
| SCHEMBL5265284 | 0.72 | CDK4 (0.86) | CCND1CDK2CDK4CCNE1CCND2 | |
| SCHEMBL23963533 | 0.72 | PIK3CD (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022177302-A1 | PYRIMIDINE-FUSED RING COMPOUND WITH DNA-PK INHIBITION ACTIVITY AND USE THEREOF | 보령제약 주식회사 | 2022-08-25 | — | — | WO | disclosed |