Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 4/20 | 0.66 |
| ▸ | BRAF | P15056 | 9/20 | 0.64 |
| ▸ | EGFR | P00533 | 7/20 | 0.61 |
| ▸ | ABL1 | P00519 | 6/20 | 0.61 |
| ▸ | JAK2 | O60674 | 1/20 | 0.61 |
| ▸ | RET | P07949 | 1/20 | 0.61 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.61 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.61 |
| ▸ | SRC | P12931 | 1/20 | 0.61 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.61 |
| ▸ | FLT1 | P17948 | 1/20 | 0.61 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.61 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.61 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.61 |
| ▸ | JAK1 | P23458 | 1/20 | 0.61 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.61 |
| ▸ | CDK2 | P24941 | 1/20 | 0.61 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.61 |
| ▸ | EPHA3 | P29320 | 1/20 | 0.61 |
| ▸ | FLT4 | P35916 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14318406 | 0.92 | KIT (0.77) | KITBRAFEGFRABL1 | |
| SCHEMBL29562197 | 0.92 | KIT (0.77) | KITBRAFEGFRABL1 | |
| Hydrochloric Acid SCHEMBL29833672 | 0.91 | KIT (0.75) | KITBRAFEGFRABL1 | |
| SCHEMBL28054362 | 0.90 | HTT (0.65) | KITBRAF | |
| SCHEMBL590507 | 0.88 | KIT (0.86) | KITBRAFEGFRABL1JAK2 | |
| SCHEMBL27997207 | 0.87 | KIT (0.61) | KITBRAFEGFRABL1 | |
| SCHEMBL17664555 | 0.85 | KIT (0.74) | KITBRAFEGFRABL1 | |
| SCHEMBL29629475 | 0.85 | KIT (0.60) | KITBRAFEGFRABL1 | |
| SCHEMBL16755299 | 0.85 | KIT (0.87) | KITBRAFEGFRABL1JAK2 | |
| SCHEMBL29562470 | 0.82 | BRAF (0.82) | KITBRAFEGFRABL1RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115279759-A | 3- ((8- ((1H-pyrazol-4-yl) amino) imidazo [1,2-a ] pyridin-3-yl) ethynyl) -N-phenylbenzamide derivative, preparation method thereof, and pharmaceutical composition for preventing or treating cancer containing same as active ingredient | 大邱庆北尖端医疗产业振兴财团 | 2022-11-01 | — | — | CN | claimed |
| CN-115279759-A | 3- ((8- ((1H-pyrazol-4-yl) amino) imidazo [1,2-a ] pyridin-3-yl) ethynyl) -N-phenylbenzamide derivative, preparation method thereof, and pharmaceutical composition for preventing or treating cancer containing same as active ingredient | 大邱庆北尖端医疗产业振兴财团 | 2022-11-01 | — | — | CN | disclosed |