Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 3/20 | 0.66 |
| ▸ | RAB9A | P51151 | 10/20 | 0.48 |
| ▸ | NPC1 | O15118 | 8/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.48 |
| ▸ | RELA | Q04206 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3003276 | 1.00 | CNR2 (0.66) | CNR2RAB9ANPC1SMN1; SMN2HPGD | |
| SCHEMBL3015071 | 0.83 | CNR2 (0.44) | CNR2ALDH1A1 | |
| SCHEMBL3015066 | 0.83 | CNR2 (0.44) | CNR2ALDH1A1 | |
| SCHEMBL3018084 | 0.81 | RARB (0.42) | CNR2RAB9ANPC1SMN1; SMN2HPGD | |
| SCHEMBL3020411 | 0.79 | CNR2 (0.64) | CNR2SMN1; SMN2HPGDALDH1A1TSHR | |
| SCHEMBL3020413 | 0.79 | CNR2 (0.64) | CNR2SMN1; SMN2HPGDALDH1A1TSHR | |
| SCHEMBL3014661 | 0.79 | CNR2 (1.00) | CNR2RAB9ANPC1SMN1; SMN2HPGD | |
| SCHEMBL3014781 | 0.75 | CNR2 (0.73) | CNR2RAB9ANPC1SMN1; SMN2HPGD | |
| SCHEMBL3007576 | 0.71 | CNR2 (1.00) | CNR2RAB9ANPC1SMN1; SMN2HPGD | |
| SCHEMBL13988490 | 0.70 | NPC1 (0.57) | RAB9ANPC1SMN1; SMN2HPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9394267-B2 | Heterocyclic modulators of cannabinoid receptors | THE CLEVELAND CLINIC FOUNDATION (US) | 2016-07-19 | — | — | US | disclosed |
| US-9339486-B2 | Heterocyclic modulators of cannabinoid receptors | THE CLEVELAND CLINIC FOUNDATION (US) | 2016-05-17 | — | — | US | disclosed |
| US-20150148408-A1 | HETEROCYCLIC MODULATORS OF CANNABINOID RECEPTORS | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2015-05-28 | — | — | US | disclosed |
| EP-2178371-B1 | HETEROCYCLIC MODULATORS OF CANNABINOID RECEPTORS | UNIV TEXAS (US) | 2014-01-01 | — | — | EP | disclosed |
| US-20130237536-A1 | HETEROCYCLIC MODULATORS OF CANNABINOID RECEPTORS | THE CLEVELAND CLINIC FOUNDATION (US) | 2013-09-12 | — | — | US | disclosed |
| US-8440832-B2 | Heterocyclic modulators of cannabinoid receptors | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2013-05-14 | — | — | US | disclosed |
| US-20100204220-A1 | HETEROCYCLIC MODULATORS OF CANNABINOID RECEPTORS | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2010-08-12 | — | — | US | disclosed |
| EP-2178371-A1 | HETEROCYCLIC MODULATORS OF CANNABINOID RECEPTORS | Board of Regents, The University of Texas System (US) | 2010-04-28 | — | — | EP | disclosed |
| WO-2009012221-A1 | HETEROCYCLIC MODULATORS OF CANNABINOID RECEPTORS | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2009-01-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100204220-A1 | HETEROCYCLIC MODULATORS OF CANNABINOID RECEPTORS | CNR1, CNR2, GPR18 | CNR2 2/4885RAB9A 1119/4885NPC1 1424/4885 |
| US-20130237536-A1 | HETEROCYCLIC MODULATORS OF CANNABINOID RECEPTORS | CNR1, CNR2, GPR18 | CNR2 2/4885RAB9A 1119/4885NPC1 1424/4885 |
| US-20150148408-A1 | HETEROCYCLIC MODULATORS OF CANNABINOID RECEPTORS | CNR1, CNR2, GPR18 | CNR2 2/4885RAB9A 1119/4885NPC1 1424/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.