Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.68 |
| ▸ | LMNA | P02545 | 3/20 | 0.68 |
| ▸ | RAB9A | P51151 | 3/20 | 0.68 |
| ▸ | HPGD | P15428 | 2/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.68 |
| ▸ | CASP3 | P42574 | 1/20 | 0.68 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.68 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.68 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.68 |
| ▸ | METAP1 | P53582 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | METAP2 | P50579 | 2/20 | 0.44 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.43 |
| ▸ | GRM5 | P41594 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5121836 | 1.00 | NPC1 (0.68) | NPC1LMNARAB9AHPGDSMN1; SMN2 | |
| SCHEMBL20665930 | 0.87 | NPC1 (0.73) | NPC1LMNARAB9AHPGDSMN1; SMN2 | |
| SCHEMBL30033460 | 0.84 | HPGD (0.82) | NPC1LMNARAB9AHPGDSMN1; SMN2 | |
| SCHEMBL26158979 | 0.84 | NPC1 (0.70) | NPC1LMNARAB9AHPGDSMN1; SMN2 | |
| SCHEMBL18998173 | 0.84 | NPC1 (0.52) | NPC1LMNARAB9AHPGDSMN1; SMN2 | |
| SCHEMBL23579763 | 0.84 | HPGD (0.82) | NPC1LMNARAB9AHPGDSMN1; SMN2 | |
| SCHEMBL2410468 | 0.82 | TGFBR1 (0.59) | NPC1LMNARAB9AHPGDSMN1; SMN2 | |
| SCHEMBL20665839 | 0.81 | SMN1; SMN2 (1.00) | NPC1LMNARAB9AHPGDSMN1; SMN2 | |
| SCHEMBL30033875 | 0.81 | SMN1; SMN2 (1.00) | NPC1LMNARAB9AHPGDSMN1; SMN2 | |
| SCHEMBL5129938 | 0.81 | NPC1 (0.45) | NPC1LMNARAB9AHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115151550-B | External nucleotide pyrophosphatase/phosphodiesterase 1 (ENPP 1) modulators and uses thereof | 桑福德·伯纳姆·普雷比医学发现研究所 | 2024-11-22 | — | — | CN | disclosed |
| EP-4081528-A1 | ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE 1 (ENPP1) MODULATORS AND USES THEREOF | Sanford Burnham Prebys Medical Discovery Institute (US) | 2022-11-02 | — | — | EP | disclosed |