Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WRN | Q14191 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25037158 | 0.96 | WRN (0.57) | WRNALDH1A1SMN1; SMN2NPSR1POLB | |
| SCHEMBL31499834 | 0.95 | WRN (0.55) | WRNALDH1A1SMN1; SMN2NPSR1POLB | |
| SCHEMBL31500574 | 0.95 | WRN (0.55) | WRNALDH1A1SMN1; SMN2NPSR1POLB | |
| SCHEMBL25037113 | 0.93 | WRN (0.56) | WRNALDH1A1SMN1; SMN2NPSR1POLB | |
| SCHEMBL30039210 | 0.91 | WRN (0.51) | WRNALDH1A1SMN1; SMN2TSHRMEN1 | |
| SCHEMBL31387134 | 0.91 | WRN (0.54) | WRNALDH1A1SMN1; SMN2NPSR1POLB | |
| SCHEMBL30037701 | 0.90 | WRN (0.51) | WRNALDH1A1SMN1; SMN2NPSR1L3MBTL1 | |
| SCHEMBL25037307 | 0.90 | WRN (0.51) | WRNALDH1A1SMN1; SMN2NPSR1L3MBTL1 | |
| SCHEMBL30037354 | 0.90 | WRN (0.43) | WRNALDH1A1SMN1; SMN2NPSR1LMNA | |
| SCHEMBL30038327 | 0.90 | WRN (0.48) | WRNALDH1A1GPR119MAPTACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4347596-A1 | TRIAZOLO-PYRIMIDINE ANALOGUES FOR TREATING DISEASES CONNECTED TO THE INHIBITON OF WERNER SYNDROME RECQ HELICASE (WRN) | Novartis AG (CH) | 2024-04-10 | — | — | EP | disclosed |
| WO-2022249060-A1 | TRIAZOLO-PYRIMIDINE ANALOGUES FOR TREATING DISEASES CONNECTED TO THE INHIBITON OF WERNER SYNDROME RECQ HELICASE (WRN) | NOVARTIS AG (CH) | 2022-12-01 | — | — | WO | disclosed |