Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL4I1 | Q96RQ9 | 8/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.37 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27163074 | 1.00 | IL4I1 (0.46) | IL4I1CYP11B1CYP11B2RXFP1TP53 | |
| SCHEMBL27163077 | 1.00 | IL4I1 (0.46) | IL4I1CYP11B1CYP11B2RXFP1TP53 | |
| SCHEMBL30180955 | 1.00 | IL4I1 (0.46) | IL4I1CYP11B1CYP11B2RXFP1TP53 | |
| SCHEMBL30046016 | 1.00 | IL4I1 (0.46) | IL4I1CYP11B1CYP11B2RXFP1TP53 | |
| SCHEMBL27163745 | 1.00 | IL4I1 (0.46) | IL4I1CYP11B1CYP11B2RXFP1TP53 | |
| SCHEMBL30046438 | 0.86 | IL4I1 (0.62) | IL4I1CYP11B1CYP11B2RXFP1TP53 | |
| SCHEMBL27163582 | 0.86 | IL4I1 (0.62) | IL4I1CYP11B1CYP11B2RXFP1TP53 | |
| SCHEMBL30047301 | 0.82 | IL4I1 (0.58) | IL4I1CYP11B1CYP11B2RXFP1TP53 | |
| SCHEMBL30046201 | 0.82 | IL4I1 (0.58) | IL4I1CYP11B1CYP11B2RXFP1TP53 | |
| SCHEMBL27163158 | 0.82 | IL4I1 (0.58) | IL4I1CYP11B1CYP11B2RXFP1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4329889-A1 | IL4I1 INHIBITORS AND METHODS OF USE | Merck Sharp & Dohme LLC (US) | 2024-03-06 | — | — | EP | disclosed |
| WO-2022227015-A1 | IL4I1 INHIBITORS AND METHODS OF USE | MERCK SHARP & DOHME CORP. (US) | 2022-11-03 | — | — | WO | disclosed |
| WO-2022232333-A1 | IL4I1 INHIBITORS AND METHODS OF USE | MERCK SHARP & DOHME LLC (US) | 2022-11-03 | — | — | WO | disclosed |