Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL4I1 | Q96RQ9 | 9/20 | 0.64 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27163789 | 1.00 | IL4I1 (0.64) | IL4I1CYP11B1CYP11B2ACHEKMT2A | |
| SCHEMBL30948020 | 0.98 | IL4I1 (0.63) | IL4I1CYP11B1CYP11B2ACHEKMT2A | |
| SCHEMBL30948249 | 0.87 | IL4I1 (0.49) | IL4I1CYP11B1CYP11B2 | |
| SCHEMBL30947909 | 0.87 | IL4I1 (0.62) | IL4I1CYP11B1CYP11B2 | |
| SCHEMBL30948078 | 0.85 | IL4I1 (0.65) | IL4I1CYP11B1CYP11B2 | |
| SCHEMBL30948097 | 0.84 | IL4I1 (0.70) | IL4I1CYP11B1CYP11B2ACHEKMT2A | |
| SCHEMBL30948219 | 0.83 | IL4I1 (0.57) | IL4I1 | |
| SCHEMBL30948039 | 0.83 | IL4I1 (0.63) | IL4I1CYP11B1CYP11B2 | |
| SCHEMBL30947966 | 0.82 | IL4I1 (0.67) | IL4I1CYP11B1CYP11B2ACHEKMT2A | |
| SCHEMBL30948185 | 0.81 | IL4I1 (0.54) | IL4I1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4329889-A1 | IL4I1 INHIBITORS AND METHODS OF USE | Merck Sharp & Dohme LLC (US) | 2024-03-06 | — | — | EP | disclosed |
| WO-2022227015-A1 | IL4I1 INHIBITORS AND METHODS OF USE | MERCK SHARP & DOHME CORP. (US) | 2022-11-03 | — | — | WO | disclosed |
| WO-2022232333-A1 | IL4I1 INHIBITORS AND METHODS OF USE | MERCK SHARP & DOHME LLC (US) | 2022-11-03 | — | — | WO | disclosed |