Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 3/20 | 0.44 |
| ▸ | CA2 | P00918 | 3/20 | 0.44 |
| ▸ | ACHE | P22303 | 2/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA4 | P22748 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 4/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23409893 | 1.00 | HTR6 (0.53) | HTR6CA1CA2ACHECA12 | |
| SCHEMBL8602545 | 0.85 | HTR6 (0.56) | HTR6CA1CA2CA12CA4 | |
| Hydrochloric Acid SCHEMBL30989178 | 0.83 | HTR6 (0.55) | HTR6CA1CA2CA12CA4 | |
| SCHEMBL28695161 | 0.81 | HTR6 (0.53) | HTR6CA1CA2CA12CA4 | |
| SCHEMBL29268394 | 0.80 | HTR6 (0.51) | HTR6CA1CA2CA12CA4 | |
| SCHEMBL3819213 | 0.79 | KMT2A (0.57) | HTR6CA12CA9KDM4EPOLB | |
| SCHEMBL8549992 | 0.77 | HTR6 (0.53) | HTR6CA1CA2CA12CA7 | |
| SCHEMBL13588814 | 0.77 | HTR6 (0.56) | HTR6CA1CA2ACHECA12 | |
| SCHEMBL15473886 | 0.76 | HTR6 (0.47) | HTR6KDM4EPOLBHTTALDH1A1 | |
| SCHEMBL31352974 | 0.76 | HTR6 (0.77) | HTR6CA1CA2CA12CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022249006-A1 | USE OF 1,2,4-OXADIAZOLE DERIVATIVES AS LIVER X RECEPTOR AGONISTS | NOVARTIS AG (CH) | 2022-12-01 | — | — | WO | disclosed |
| EP-4065228-A1 | 1,2,4-OXADIAZOLE DERIVATIVES AS LIVER X RECEPTOR AGONISTS | Novartis AG (CH) | 2022-10-05 | — | — | EP | disclosed |