Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 2/20 | 0.65 |
| ▸ | EGFR | P00533 | 2/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.35 |
| ▸ | MME | P08473 | 2/20 | 0.34 |
| ▸ | CTSV | O60911 | 2/20 | 0.34 |
| ▸ | CTSL | P07711 | 2/20 | 0.34 |
| ▸ | CTSS | P25774 | 2/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
| ▸ | MMEL1 | Q495T6 | 1/20 | 0.34 |
| ▸ | FFAR2 | O15552 | 2/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL300535 | 1.00 | CNR2 (0.65) | CNR2EGFRPTGS2PARP1ADRB3 | |
| SCHEMBL300497 | 0.90 | CNR2 (0.78) | CNR2 | |
| SCHEMBL300356 | 0.90 | CNR2 (0.78) | CNR2 | |
| SCHEMBL300479 | 0.90 | CNR2 (0.78) | CNR2 | |
| SCHEMBL300487 | 0.90 | CNR2 (0.78) | CNR2 | |
| SCHEMBL300533 | 0.90 | CNR2 (0.78) | CNR2 | |
| SCHEMBL300463 | 0.90 | CNR2 (0.78) | CNR2 | |
| SCHEMBL176480 | 0.88 | CNR2 (0.80) | CNR2EGFRPTGS2PARP1MME | |
| SCHEMBL176535 | 0.88 | CNR2 (0.80) | CNR2EGFRPTGS2PARP1MME | |
| SCHEMBL176651 | 0.79 | CNR2 (1.00) | CNR2CTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937259-B1 | HEXAHYDRO-CYCLOHEPTAPYRAZOLE CANNABINOID MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2011-11-23 | — | — | EP | claimed |