SCHEMBL30048944

SCHEMBL30048944

Cc1nnc2nc(N(CC(F)F)c3cc(F)cc(C#CC4(C)COC4)c3)c3cc(F)ccc3n12

nearest known ligand 0.30

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
PTAFR P25105 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24814734 1.00 PTAFR (0.30) PTAFR
SCHEMBL23577576 0.93 PTAFR (0.32) PTAFR
SCHEMBL29909164 0.93 PTAFR (0.32) PTAFR
SCHEMBL30047986 0.86
SCHEMBL24814621 0.86
SCHEMBL23601555 0.83 TNIK (0.34) PTAFR
SCHEMBL24816043 0.81 PTAFR (0.31) PTAFR
SCHEMBL24721217 0.81 PTAFR (0.31) PTAFR
SCHEMBL23601469 0.81 NQO2 (0.32) PTAFR
SCHEMBL23576834 0.81

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4359415-A1 DIACYLGLYERCOL KINASE MODULATING COMPOUNDS GILEAD SCIENCES, INC. (US) 2024-05-01 EP disclosed
WO-2022271684-A1 DIACYLGLYERCOL KINASE MODULATING COMPOUNDS GILEAD SCIENCES, INC. (US) 2022-12-29 WO disclosed