Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.54 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30920891 | 0.73 | PTAFR (0.36) | SMN1; SMN2L3MBTL1PBRM1KDM4EMEN1 | |
| SCHEMBL30013170 | 0.72 | SMN1; SMN2 (0.34) | SMN1; SMN2L3MBTL1PBRM1 | |
| SCHEMBL11777629 | 0.70 | SMN1; SMN2 (1.00) | SMN1; SMN2L3MBTL1PBRM1KDM4EPOLB | |
| SCHEMBL11707641 | 0.67 | POLB (0.56) | SMN1; SMN2L3MBTL1PBRM1KDM4EMEN1 | |
| SCHEMBL30978999 | 0.67 | KDM4E (0.42) | SMN1; SMN2L3MBTL1PBRM1KDM4EMEN1 | |
| SCHEMBL12841562 | 0.66 | KMT2A (0.56) | SMN1; SMN2L3MBTL1PBRM1KDM4EMEN1 | |
| SCHEMBL4510784 | 0.66 | SMN1; SMN2 (0.39) | SMN1; SMN2L3MBTL1PBRM1KDM4EKMT2A | |
| SCHEMBL29354440 | 0.66 | SMN1; SMN2 (0.39) | SMN1; SMN2L3MBTL1PBRM1KDM4EKMT2A | |
| SCHEMBL8518248 | 0.66 | TNKS2 (0.40) | SMN1; SMN2KDM4EPOLBHSD17B10HPGD | |
| SCHEMBL5656535 | 0.66 | KMT2A (0.44) | SMN1; SMN2L3MBTL1KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4359415-A1 | DIACYLGLYERCOL KINASE MODULATING COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2024-05-01 | — | — | EP | disclosed |
| WO-2022271684-A1 | DIACYLGLYERCOL KINASE MODULATING COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2022-12-29 | — | — | WO | disclosed |