Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | GPR3 | P46089 | 1/20 | 0.33 |
| ▸ | TERT | O14746 | 1/20 | 0.33 |
| ▸ | HTR3A | P46098 | 1/20 | 0.33 |
| ▸ | DAO | P14920 | 2/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | KMO | O15229 | 1/20 | 0.32 |
| ▸ | GMNN | O75496 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4510784 | 1.00 | SMN1; SMN2 (0.39) | SMN1; SMN2PBRM1L3MBTL1CYP1A2CYP2A6 | |
| SCHEMBL26976529 | 0.88 | MAPT (0.47) | MAPT | |
| SCHEMBL29511699 | 0.82 | KDM4E (0.42) | SMN1; SMN2PBRM1L3MBTL1CYP1A2CYP2A6 | |
| SCHEMBL29511771 | 0.78 | SMN1; SMN2 (0.41) | SMN1; SMN2PBRM1L3MBTL1CYP1A2CYP2A6 | |
| SCHEMBL29511735 | 0.78 | SMN1; SMN2 (0.34) | SMN1; SMN2PBRM1L3MBTL1CYP2A6 | |
| SCHEMBL29511741 | 0.73 | THRB (0.39) | SMN1; SMN2PBRM1L3MBTL1CYP1A2MAPT | |
| SCHEMBL9601313 | 0.71 | CLK4 (0.36) | SMN1; SMN2PBRM1L3MBTL1CYP1A2MAPT | |
| SCHEMBL30649148 | 0.69 | TERT (0.36) | SMN1; SMN2PBRM1L3MBTL1CYP1A2MAPT | |
| SCHEMBL29881244 | 0.69 | NPSR1 (0.47) | MAPTKMT2AKDM4EADORA3ALDH1A1 | |
| SCHEMBL4511748 | 0.68 | ALDH1A1 (0.50) | SMN1; SMN2CYP1A2MAPTKMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112321593-B | Preparation method of indolo [1,2-a ] quinazoline-6 (5H) -ketone compound | 浙江理工大学 | 2022-03-18 | — | — | CN | claimed |
| WO-2024192064-A1 | COMPOUNDS AND COMPOSITIONS AS SMARCA2/4 DEGRADERS AND USES THEREOF | ONCOPIA THERAPEUTICS, INC. D/B/A/ PROTEOVANT THERAPEUTICS, INC. (US) | 2024-09-19 | — | — | WO | disclosed |
| WO-2024064316-A1 | COMPOUNDS AND COMPOSITIONS AS SMARCA2/4 INHIBITORS AND USES THEREOF | REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2024-03-28 | — | — | WO | disclosed |
| CN-109562111-B | CK2 inhibitors, compositions and methods thereof | 北极星药业股份有限公司 | 2023-04-04 | — | — | CN | disclosed |
| CN-112321593-B | Preparation method of indolo [1,2-a ] quinazoline-6 (5H) -ketone compound | 浙江理工大学 | 2022-03-18 | — | — | CN | disclosed |
| CN-112321593-B | Preparation method of indolo [1,2-a ] quinazoline-6 (5H) -ketone compound | 浙江理工大学 | 2022-03-18 | — | — | CN | disclosed |
| CN-112321593-B | Preparation method of indolo [1,2-a ] quinazoline-6 (5H) -ketone compound | 浙江理工大学 | 2022-03-18 | — | — | CN | disclosed |