Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.40 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 2/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 3/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27161719 | 1.00 | ALDH1A1 (0.41) | ALDH1A1SMN1; SMN2LMNACYP2D6SSTR5 | |
| SCHEMBL30050112 | 0.95 | ALDH1A1 (0.38) | ALDH1A1SMN1; SMN2LMNACYP2D6SSTR5 | |
| SCHEMBL27162170 | 0.95 | ALDH1A1 (0.38) | ALDH1A1SMN1; SMN2LMNACYP2D6SSTR5 | |
| SCHEMBL30050705 | 0.91 | CYP3A4 (0.40) | ALDH1A1SMN1; SMN2LMNACYP2D6L3MBTL1 | |
| SCHEMBL30050026 | 0.91 | CYP3A4 (0.44) | ALDH1A1SMN1; SMN2LMNACYP2D6L3MBTL1 | |
| SCHEMBL27161544 | 0.91 | CYP3A4 (0.44) | ALDH1A1SMN1; SMN2LMNACYP2D6L3MBTL1 | |
| SCHEMBL27162324 | 0.91 | CYP3A4 (0.40) | ALDH1A1SMN1; SMN2LMNACYP2D6L3MBTL1 | |
| SCHEMBL30050034 | 0.90 | SMN1; SMN2 (0.43) | ALDH1A1SMN1; SMN2LMNACYP2D6SSTR5 | |
| SCHEMBL27162198 | 0.90 | SMN1; SMN2 (0.43) | ALDH1A1SMN1; SMN2LMNACYP2D6SSTR5 | |
| SCHEMBL30049542 | 0.85 | SMN1; SMN2 (0.40) | ALDH1A1SMN1; SMN2LMNACYP2D6KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4330248-A1 | PYRIDINE-SULFONAMIDE DERIVATIVES AS SIGMA LIGANDS | Acondicionamiento Tarrasense (ES) | 2024-03-06 | — | — | EP | claimed |
| WO-2022229405-A1 | PYRIDINE-SULFONAMIDE DERIVATIVES AS SIGMA LIGANDS | ACONDICIONAMIENTO TARRASENSE (ES) | 2022-11-03 | — | — | WO | claimed |
| EP-4330248-A1 | PYRIDINE-SULFONAMIDE DERIVATIVES AS SIGMA LIGANDS | Acondicionamiento Tarrasense (ES) | 2024-03-06 | — | — | EP | disclosed |
| WO-2022229405-A1 | PYRIDINE-SULFONAMIDE DERIVATIVES AS SIGMA LIGANDS | ACONDICIONAMIENTO TARRASENSE (ES) | 2022-11-03 | — | — | WO | disclosed |