Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 8/20 | 0.55 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.55 |
| ▸ | AURKA | O14965 | 5/20 | 0.55 |
| ▸ | MET | P08581 | 5/20 | 0.55 |
| ▸ | TEK | Q02763 | 5/20 | 0.55 |
| ▸ | ABL1 | P00519 | 2/20 | 0.49 |
| ▸ | LCK | P06239 | 1/20 | 0.49 |
| ▸ | LYN | P07948 | 1/20 | 0.49 |
| ▸ | RET | P07949 | 8/20 | 0.48 |
| ▸ | AXL | P30530 | 2/20 | 0.47 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.46 |
| ▸ | ERN1 | O75460 | 1/20 | 0.46 |
| ▸ | STK10 | O94804 | 1/20 | 0.46 |
| ▸ | MAP3K6 | O95382 | 1/20 | 0.46 |
| ▸ | ESR1 | P03372 | 1/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | KIT | P10721 | 1/20 | 0.46 |
| ▸ | BCR | P11274 | 1/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29186565 | 1.00 | KDR (0.55) | KDRAURKBAURKAMETTEK | |
| SCHEMBL30050356 | 0.93 | KDR (0.59) | KDRAURKBAURKAMETTEK | |
| SCHEMBL29317871 | 0.93 | KDR (0.59) | KDRAURKBAURKAMETTEK | |
| SCHEMBL29317818 | 0.93 | KDR (0.61) | KDRAURKBAURKAMETTEK | |
| SCHEMBL30050696 | 0.93 | KDR (0.61) | KDRAURKBAURKAMETTEK | |
| SCHEMBL30050941 | 0.89 | KDR (0.57) | KDRAURKBAURKAMETTEK | |
| SCHEMBL29317820 | 0.89 | KDR (0.57) | KDRAURKBAURKAMETTEK | |
| SCHEMBL29319922 | 0.89 | KDR (0.57) | KDRAURKBAURKAMETTEK | |
| SCHEMBL29186530 | 0.84 | MET (0.45) | KDRAURKBAURKAMETTEK | |
| SCHEMBL30049826 | 0.84 | MET (0.45) | KDRAURKBAURKAMETTEK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4330233-A1 | PHENYL -O-QUINOLINE, QUINAZOLINE, THIENOPYRIDINE, THIENOPYRIMIDINE, PYRROLOPYRIDINE, PYRROLOPYRIMIDINE COMPOUNDS HAVING ANTICANCER ACTIVITY | Chengdu Anticancer Bioscience, Ltd. (CN) | 2024-03-06 | — | — | EP | disclosed |
| WO-2022228549-A1 | PHENYL -O-QUINOLINE, QUINAZOLINE, THIENOPYRIDINE, THIENOPYRIMIDINE, PYRROLOPYRIDINE, PYRROLOPYRIMIDINE COMPOUNDS HAVING ANTICANCER ACTIVITY | Chengdu Anticancer Bioscience, Ltd. (CN) | 2022-11-03 | — | — | WO | disclosed |