Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 2/20 | 0.51 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.46 |
| ▸ | FGFR3 | P22607 | 11/20 | 0.45 |
| ▸ | FGFR2 | P21802 | 9/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 8/20 | 0.45 |
| ▸ | FGFR4 | P22455 | 8/20 | 0.45 |
| ▸ | KDR | P35968 | 7/20 | 0.45 |
| ▸ | FLT3 | P36888 | 2/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.43 |
| ▸ | BCR | P11274 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29186516 | 1.00 | ERN1 (0.51) | ERN1LOXL2FGFR3FGFR2FGFR1 | |
| SCHEMBL19259702 | 0.82 | LOXL2 (0.46) | ERN1LOXL2FGFR3FGFR2FGFR1 | |
| SCHEMBL30148177 | 0.82 | ABL1 (0.46) | ERN1FGFR3FGFR2ABL1BCR | |
| SCHEMBL24732299 | 0.78 | LOXL2 (0.44) | ERN1LOXL2FGFR3FGFR2FGFR1 | |
| SCHEMBL15416714 | 0.77 | ERN1 (0.46) | ERN1PDK2 | |
| SCHEMBL29431746 | 0.77 | ERN1 (0.52) | ERN1LOXL2PDK2 | |
| SCHEMBL24921266 | 0.77 | CYP1A1 (0.52) | ERN1FGFR3FGFR2FGFR1FGFR4 | |
| SCHEMBL1571332 | 0.77 | ERN1 (0.46) | ERN1LOXL2PDK2 | |
| SCHEMBL14146277 | 0.76 | ERN1 (0.47) | ERN1LOXL2FGFR3FGFR2FGFR1 | |
| SCHEMBL30667451 | 0.76 | FGFR2 (0.46) | ERN1LOXL2FGFR3FGFR2FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4330233-A1 | PHENYL -O-QUINOLINE, QUINAZOLINE, THIENOPYRIDINE, THIENOPYRIMIDINE, PYRROLOPYRIDINE, PYRROLOPYRIMIDINE COMPOUNDS HAVING ANTICANCER ACTIVITY | Chengdu Anticancer Bioscience, Ltd. (CN) | 2024-03-06 | — | — | EP | disclosed |
| CN-117321036-A | phenyl-O-quinoline, quinazoline, thienopyridine, thienopyrimidine, pyrrolopyridine, pyrrolopyrimidine compounds having anticancer activity | 成都安泰康赛生物科技有限公司 | 2023-12-29 | — | — | CN | disclosed |
| WO-2022228549-A1 | PHENYL -O-QUINOLINE, QUINAZOLINE, THIENOPYRIDINE, THIENOPYRIMIDINE, PYRROLOPYRIDINE, PYRROLOPYRIMIDINE COMPOUNDS HAVING ANTICANCER ACTIVITY | Chengdu Anticancer Bioscience, Ltd. (CN) | 2022-11-03 | — | — | WO | disclosed |