Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDR2 | Q16832 | 1/20 | 0.56 |
| ▸ | MET | P08581 | 4/20 | 0.46 |
| ▸ | AXL | P30530 | 4/20 | 0.46 |
| ▸ | MERTK | Q12866 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 4/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | TEK | Q02763 | 1/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 4/20 | 0.44 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | GAK | O14976 | 1/20 | 0.42 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.42 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.42 |
| ▸ | STK16 | O75716 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.42 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.42 |
| ▸ | COQ8A | Q8NI60 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29186585 | 1.00 | DDR2 (0.56) | DDR2METAXLMERTKKDR | |
| SCHEMBL29318284 | 0.89 | MET (0.45) | DDR2METAXLMERTKKDR | |
| SCHEMBL29186574 | 0.86 | KDR (0.52) | DDR2METAXLKDRAURKA | |
| SCHEMBL30050441 | 0.86 | EGFR (0.58) | DDR2KDREGFRPDGFRAGAK | |
| SCHEMBL27159593 | 0.86 | EGFR (0.58) | DDR2KDREGFRPDGFRAGAK | |
| SCHEMBL29186558 | 0.85 | KDR (0.46) | DDR2METAXLMERTKKDR | |
| SCHEMBL30050085 | 0.85 | KDR (0.46) | DDR2METAXLMERTKKDR | |
| SCHEMBL30049303 | 0.85 | DDR2 (0.54) | DDR2METAXLMERTKKDR | |
| SCHEMBL29318681 | 0.85 | DDR2 (0.54) | DDR2METAXLMERTKKDR | |
| SCHEMBL30050234 | 0.84 | DDR2 (0.53) | DDR2METAXLMERTKKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4330233-A1 | PHENYL -O-QUINOLINE, QUINAZOLINE, THIENOPYRIDINE, THIENOPYRIMIDINE, PYRROLOPYRIDINE, PYRROLOPYRIMIDINE COMPOUNDS HAVING ANTICANCER ACTIVITY | Chengdu Anticancer Bioscience, Ltd. (CN) | 2024-03-06 | — | — | EP | disclosed |
| WO-2022228549-A1 | PHENYL -O-QUINOLINE, QUINAZOLINE, THIENOPYRIDINE, THIENOPYRIMIDINE, PYRROLOPYRIDINE, PYRROLOPYRIMIDINE COMPOUNDS HAVING ANTICANCER ACTIVITY | Chengdu Anticancer Bioscience, Ltd. (CN) | 2022-11-03 | — | — | WO | disclosed |