Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.33 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.33 |
| ▸ | HTR1A known ✓ | P08908 | 1/20 | 0.32 |
| ▸ | ADRA1D known ✓ | P25100 | 1/20 | 0.32 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.32 |
| ▸ | ADRA1B known ✓ | P35368 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | CYBB | P04839 | 1/20 | 0.36 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.36 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 3/20 | 0.34 |
| ▸ | DRD4 | P21917 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL28415457 | 1.00 | MAPT (0.39) | MAPTALDH1A1HPGDMCL1TDP1 | |
| SCHEMBL28412475 | 0.99 | MAPT (0.40) | MAPTALDH1A1HPGDMCL1TDP1 | |
| Bromide SCHEMBL30054351 | 0.94 | CYBB (0.39) | MAPTALDH1A1HPGDMCL1TDP1 | |
| SCHEMBL30054230 | 0.93 | CYBB (0.40) | MAPTALDH1A1HPGDMCL1TDP1 | |
| SCHEMBL28421835 | 0.87 | MAPT (0.41) | MAPTALDH1A1HPGDMCL1TDP1 | |
| SCHEMBL30052960 | 0.87 | MAPT (0.41) | MAPTALDH1A1HPGDMCL1TDP1 | |
| Bromide SCHEMBL30054556 | 0.86 | NPSR1 (0.37) | MAPTALDH1A1HPGDMCL1TDP1 | |
| Bromide SCHEMBL28412751 | 0.86 | DRD2 (0.41) | MAPTALDH1A1HPGDDRD2DRD4 | |
| SCHEMBL28891609 | 0.85 | MEN1 (0.42) | MAPTALDH1A1DRD2DRD4MEN1 | |
| SCHEMBL30056333 | 0.85 | MEN1 (0.42) | MAPTALDH1A1DRD2DRD4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111315829-B | Small molecule organic dye | 巴塞尔大学 | 2022-11-04 | — | — | CN | disclosed |