Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 7/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lhf-535 SCHEMBL15201606 | 1.00 | FGFR1 (0.53) | FGFR1SMN1; SMN2ALDH1A1MAPTGABRA1 | |
| Lhf-535 SCHEMBL15201523 | 1.00 | FGFR1 (0.53) | FGFR1SMN1; SMN2ALDH1A1MAPTGABRA1 | |
| SCHEMBL15201393 | 0.91 | FGFR1 (0.55) | FGFR1SMN1; SMN2ALDH1A1MAPTHPGD | |
| SCHEMBL15201394 | 0.91 | FGFR1 (0.55) | FGFR1SMN1; SMN2ALDH1A1MAPTHPGD | |
| SCHEMBL15201708 | 0.91 | FGFR1 (0.55) | FGFR1SMN1; SMN2ALDH1A1MAPTHPGD | |
| SCHEMBL15201677 | 0.91 | FGFR1 (0.50) | FGFR1SMN1; SMN2ALDH1A1MAPTHPGD | |
| SCHEMBL15201674 | 0.91 | FGFR1 (0.50) | FGFR1SMN1; SMN2ALDH1A1MAPTHPGD | |
| SCHEMBL15201439 | 0.90 | FGFR1 (0.54) | FGFR1SMN1; SMN2ALDH1A1MAPTHPGD | |
| SCHEMBL15201438 | 0.90 | FGFR1 (0.54) | FGFR1SMN1; SMN2ALDH1A1MAPTHPGD | |
| SCHEMBL15202445 | 0.90 | FGFR1 (0.49) | FGFR1SMN1; SMN2ALDH1A1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12098151-B2 | Arenavirus growth inhibitor comprising polycyclic carbamoyl pyridone derivative | NATIONAL UNIVERSITY COPORATION HOKKAIDO UNIVERSITY (JP) | 2024-09-24 | — | — | US | disclosed |
| US-20230210816-A1 | INHIBITION OF ARENAVIRUSES BY COMBINATIONS OF APPROVED THERAPEUTIC DRUGS | UNIVERSITY OF WASHINGTON (US) | 2023-07-06 | — | — | US | disclosed |
| CN-116217490-A | Benzimidazole compound, and preparation method and application thereof | 中国人民解放军军事科学院军事医学研究院 | 2023-06-06 | — | — | CN | disclosed |
| US-20230117695-A1 | ARENAVIRUS GROWTH INHIBITOR COMPRISING POLYCYCLIC CARBAMOYL PYRIDONE DERIVATIVE | NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (JP) | 2023-04-20 | — | — | US | disclosed |
| US-11492352-B2 | Arenavirus growth inhibitor comprising polycyclic carbamoylpyridone derivative | NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (JP) | 2022-11-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11492352-B2 | Arenavirus growth inhibitor comprising polycyclic carbamoylpyridone derivative | LUC7L2, CXCR6, RRP12 | FGFR1 680/4885SMN1; SMN2 2811/4885ALDH1A1 4161/4885 |
| US-12098151-B2 | Arenavirus growth inhibitor comprising polycyclic carbamoyl pyridone derivative | CDK7, CCNA1, CCR10 | FGFR1 809/4885SMN1; SMN2 2791/4885ALDH1A1 4229/4885 |
| US-20230117695-A1 | ARENAVIRUS GROWTH INHIBITOR COMPRISING POLYCYCLIC CARBAMOYL PYRIDONE DERIVATIVE | CDK7, CCNA1, CCR10 | FGFR1 817/4885SMN1; SMN2 2820/4885ALDH1A1 4215/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.