Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 14/20 | 0.66 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.41 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21496401 | 1.00 | IDO1 (0.66) | IDO1MEN1ALDH1A1MAPTTHRB | |
| SCHEMBL24117968 | 0.94 | IDO1 (0.65) | IDO1MEN1ALDH1A1MAPTTHRB | |
| SCHEMBL21496395 | 0.94 | IDO1 (0.65) | IDO1MEN1ALDH1A1MAPTTHRB | |
| SCHEMBL21496346 | 0.81 | IDO1 (0.68) | IDO1MEN1ALDH1A1HTTKMT2A | |
| SCHEMBL30057665 | 0.81 | IDO1 (0.68) | IDO1MEN1ALDH1A1HTTKMT2A | |
| SCHEMBL21496285 | 0.79 | IDO1 (1.00) | IDO1MEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL30055680 | 0.79 | IDO1 (1.00) | IDO1MEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL24118301 | 0.79 | IDO1 (1.00) | IDO1MEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL21496286 | 0.79 | IDO1 (1.00) | IDO1MEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL24118331 | 0.79 | IDO1 (0.83) | IDO1MEN1ALDH1A1MAPTTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11478461-B2 | [1.1.1] bicyclo compounds as indoleamine 2,3-dioxygenase inhibitors | MERCK SHARP & DOHME LLC (US) | 2022-10-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11478461-B2 | [1.1.1] bicyclo compounds as indoleamine 2,3-dioxygenase inhibitors | IDO1, IDO2, KYNU | IDO1 1/4885MEN1 1030/4885ALDH1A1 133/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.