Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 14/20 | 0.80 |
| ▸ | FPR2 | P25090 | 1/20 | 0.42 |
| ▸ | GRM5 | P41594 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21496359 | 1.00 | IDO1 (0.80) | IDO1FPR2GRM5CYP1A2CYP3A4 | |
| SCHEMBL21496407 | 0.89 | IDO1 (1.00) | IDO1 | |
| SCHEMBL21504226 | 0.88 | IDO1 (1.00) | IDO1FPR2GRM5SMN1; SMN2 | |
| SCHEMBL30056397 | 0.88 | IDO1 (1.00) | IDO1FPR2GRM5SMN1; SMN2 | |
| SCHEMBL30056253 | 0.88 | IDO1 (1.00) | IDO1FPR2GRM5SMN1; SMN2 | |
| SCHEMBL21496511 | 0.86 | IDO1 (0.76) | IDO1HTR2B | |
| SCHEMBL30055491 | 0.86 | IDO1 (0.76) | IDO1HTR2B | |
| SCHEMBL21496521 | 0.86 | IDO1 (0.76) | IDO1HTR2B | |
| SCHEMBL21496512 | 0.86 | IDO1 (0.76) | IDO1HTR2B | |
| SCHEMBL30055271 | 0.86 | IDO1 (0.76) | IDO1HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11478461-B2 | [1.1.1] bicyclo compounds as indoleamine 2,3-dioxygenase inhibitors | MERCK SHARP & DOHME LLC (US) | 2022-10-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11478461-B2 | [1.1.1] bicyclo compounds as indoleamine 2,3-dioxygenase inhibitors | IDO1, IDO2, KYNU | IDO1 1/4885FPR2 1585/4885GRM5 849/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.