Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL30056260 | 0.89 | IRAK4 (0.30) | PKM | |
| SCHEMBL17645128 | 0.84 | HTR2C (0.32) | — | |
| SCHEMBL20898613 | 0.84 | HTR2C (0.32) | — | |
| SCHEMBL17630240 | 0.84 | HTR2C (0.32) | — | |
| Trifluoroacetic Acid SCHEMBL28320686 | 0.76 | DPP4 (0.34) | PKM | |
| Trifluoroacetic Acid SCHEMBL2917931 | 0.75 | PKM (0.36) | PKM | |
| Trifluoroacetic Acid SCHEMBL21816594 | 0.75 | PKM (0.36) | PKM | |
| Trifluoroacetic Acid SCHEMBL21816711 | 0.75 | PKM (0.36) | PKM | |
| Trifluoroacetic Acid SCHEMBL20236674 | 0.75 | PKM (0.36) | PKM | |
| Trifluoroacetic Acid SCHEMBL17262311 | 0.75 | PKM (0.36) | PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3694331-B1 | INDAZOLYL-SPIRO[2.3]HEXANE-CARBONITRILE DERIVATIVES AS LRRK2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF | MERCK SHARP & DOHME LLC (US) | 2022-11-16 | — | — | EP | disclosed |