Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 15/20 | 0.75 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.40 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21496540 | 1.00 | IDO1 (0.75) | IDO1P2RX7MAPTCSNK1DCSNK1E | |
| SCHEMBL21496541 | 1.00 | IDO1 (0.75) | IDO1P2RX7MAPTCSNK1DCSNK1E | |
| SCHEMBL24118627 | 0.87 | IDO1 (0.80) | IDO1MAPT | |
| SCHEMBL30055212 | 0.87 | IDO1 (0.80) | IDO1MAPT | |
| SCHEMBL21496352 | 0.86 | IDO1 (1.00) | IDO1MAPT | |
| SCHEMBL21496354 | 0.86 | IDO1 (1.00) | IDO1MAPT | |
| SCHEMBL24118186 | 0.86 | IDO1 (1.00) | IDO1MAPT | |
| SCHEMBL23271162 | 0.84 | IDO1 (0.56) | IDO1 | |
| SCHEMBL29639833 | 0.84 | IDO1 (0.56) | IDO1 | |
| SCHEMBL21496325 | 0.82 | IDO1 (0.72) | IDO1MAPTIRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11478461-B2 | [1.1.1] bicyclo compounds as indoleamine 2,3-dioxygenase inhibitors | MERCK SHARP & DOHME LLC (US) | 2022-10-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11478461-B2 | [1.1.1] bicyclo compounds as indoleamine 2,3-dioxygenase inhibitors | IDO1, IDO2, KYNU | IDO1 1/4885P2RX7 2566/4885MAPT 1461/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.