SCHEMBL30057560

SCHEMBL30057560

COc1ccc(COCn2cncc2CC(NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)O)cc1

nearest known ligand 0.51

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ MDM2 Q00987 7/20 0.51
▸ MDM4 O15151 3/20 0.46
▸ TP53 P04637 3/20 0.46
▸ TNF P01375 1/20 0.42
▸ ATM Q13315 1/20 0.40
▸ SLC17A5 Q9NRA2 1/20 0.39
▸ CASP3 P42574 1/20 0.39
▸ TLR2 O60603 1/20 0.39
▸ ITGA4 P13612 1/20 0.38
▸ ITGB7 P26010 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30057098 1.00 MDM2 (0.51) MDM2MDM4TP53TNFATM
SCHEMBL119712 0.93 MDM4 (0.49) MDM2MDM4TP53TNFSLC17A5
SCHEMBL5717685 0.93 MDM4 (0.49) MDM2MDM4TP53TNFSLC17A5
SCHEMBL30196497 0.93 MDM4 (0.49) MDM2MDM4TP53TNFSLC17A5
SCHEMBL31370433 0.85 MDM2 (0.49) MDM2MDM4TP53TNFATM
SCHEMBL13470198 0.83 MDM4 (0.52) MDM2MDM4TP53CASP3TLR2
SCHEMBL31369496 0.83 MDM2 (0.48) MDM2MDM4TP53TNFATM
SCHEMBL28812446 0.81 MDM2 (0.56) MDM2MDM4TP53TNFATM
SCHEMBL28812447 0.81 MDM2 (0.56) MDM2MDM4TP53TNFATM
SCHEMBL29802960 0.81 MDM2 (0.56) MDM2MDM4TP53TNFATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115433266-A Solid-phase synthesis method of teriparatide 台州吉诺生物科技有限公司 2022-12-06 — — CN claimed
CN-115433266-A Solid-phase synthesis method of teriparatide 台州吉诺生物科技有限公司 2022-12-06 — — CN disclosed
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