Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CPB1 | P15086 | 2/20 | 0.90 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.58 |
| ▸ | TSHR | P16473 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | CTSB | P07858 | 2/20 | 0.50 |
| ▸ | CTSS | P25774 | 2/20 | 0.50 |
| ▸ | CTSK | P43235 | 2/20 | 0.50 |
| ▸ | CTSL | P07711 | 1/20 | 0.50 |
| ▸ | CASP3 | P42574 | 3/20 | 0.49 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12193443 | 1.00 | CPB1 (0.90) | CPB1CYP2C9CYP2C19TSHRALDH1A1 | |
| SCHEMBL2497897 | 1.00 | CPB1 (0.90) | CPB1CYP2C9CYP2C19TSHRALDH1A1 | |
| SCHEMBL23089809 | 1.00 | CPB1 (0.90) | CPB1CYP2C9CYP2C19TSHRALDH1A1 | |
| SCHEMBL4481541 | 0.92 | CPB1 (0.78) | CPB1CYP2C9CYP2C19TSHRALDH1A1 | |
| SCHEMBL10303639 | 0.92 | CPB1 (0.78) | CPB1CYP2C9CYP2C19TSHRALDH1A1 | |
| SCHEMBL13712268 | 0.92 | CPB1 (0.78) | CPB1CYP2C9CYP2C19TSHRALDH1A1 | |
| SCHEMBL14161287 | 0.92 | CPB1 (0.78) | CPB1CYP2C9CYP2C19TSHRALDH1A1 | |
| SCHEMBL28376595 | 0.92 | CPB1 (0.78) | CPB1CYP2C9CYP2C19TSHRALDH1A1 | |
| SCHEMBL30135204 | 0.92 | CPB1 (0.77) | CPB1TSHRALDH1A1GAACTSB | |
| SCHEMBL10916786 | 0.91 | CPB1 (0.77) | CPB1CYP2C9CYP2C19TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230115534-A1 | PROGRANULIN MODULATORS AND METHODS OF USING THE SAME | ARKUDA THERAPEUTICS | 2023-04-13 | — | — | US | disclosed |
| EP-4077283-A1 | PROGRANULIN MODULATORS AND METHODS OF USING THE SAME | Arkuda Therapeutics (US) | 2022-10-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230115534-A1 | PROGRANULIN MODULATORS AND METHODS OF USING THE SAME | GRN, PSEN1, PSEN2 | CPB1 404/4885CYP2C9 4848/4885CYP2C19 4701/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.