Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | BLM | P54132 | 1/20 | 0.56 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.52 |
| ▸ | RAD52 | P43351 | 1/20 | 0.50 |
| ▸ | KDM1A | O60341 | 2/20 | 0.42 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.39 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 4/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24781342 | 1.00 | KDM4E (0.56) | KDM4EMAPTCYP2C19ALDH1A1POLB | |
| SCHEMBL17605162 | 0.91 | KDM4E (0.68) | KDM4EMAPTCYP2C19ALDH1A1POLB | |
| SCHEMBL29802007 | 0.91 | KDM4E (0.68) | KDM4EMAPTCYP2C19ALDH1A1POLB | |
| SCHEMBL17604912 | 0.91 | KDM4E (0.68) | KDM4EMAPTCYP2C19ALDH1A1POLB | |
| SCHEMBL7405059 | 0.82 | KDM4E (0.83) | KDM4EMAPTCYP2C19ALDH1A1POLB | |
| SCHEMBL23976461 | 0.82 | KDM4E (0.56) | KDM4EMAPTCYP2C19ALDH1A1POLB | |
| SCHEMBL9178817 | 0.78 | KDM1A (0.56) | KDM4EMAPTCYP2C19ALDH1A1POLB | |
| SCHEMBL60004 | 0.78 | RAD52 (0.55) | KDM4EMAPTCYP2C19ALDH1A1POLB | |
| Hydrochloric Acid SCHEMBL11149959 | 0.76 | RAD52 (0.53) | KDM4EMAPTCYP2C19ALDH1A1POLB | |
| SCHEMBL7406173 | 0.74 | KDM4E (0.66) | KDM4EMAPTCYP2C19ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115485275-A | Compounds and compositions that inhibit HIF 2-alpha activity and methods of use thereof | 诺华股份有限公司 | 2022-12-16 | — | — | CN | disclosed |