Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.68 |
| ▸ | MAPT | P10636 | 3/20 | 0.68 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.68 |
| ▸ | POLB | P06746 | 2/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.68 |
| ▸ | BLM | P54132 | 1/20 | 0.68 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.68 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.68 |
| ▸ | MEN1 | O00255 | 1/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.68 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.62 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.62 |
| ▸ | KDM1A | O60341 | 3/20 | 0.41 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.41 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.41 |
| ▸ | RAD52 | P43351 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17605162 | 1.00 | KDM4E (0.68) | KDM4EMAPTCYP2C19POLBALDH1A1 | |
| SCHEMBL17604912 | 1.00 | KDM4E (0.68) | KDM4EMAPTCYP2C19POLBALDH1A1 | |
| SCHEMBL24781342 | 0.91 | KDM4E (0.56) | KDM4EMAPTCYP2C19POLBALDH1A1 | |
| SCHEMBL30060641 | 0.91 | KDM4E (0.56) | KDM4EMAPTCYP2C19POLBALDH1A1 | |
| SCHEMBL7403597 | 0.82 | KDM4E (0.69) | KDM4EMAPTCYP2C19POLBALDH1A1 | |
| SCHEMBL17605639 | 0.82 | KDM4E (0.47) | KDM4EMAPTCYP2C19POLBALDH1A1 | |
| SCHEMBL17605640 | 0.82 | KDM4E (0.47) | KDM4EMAPTCYP2C19POLBALDH1A1 | |
| SCHEMBL1809924 | 0.81 | KDM4E (1.00) | KDM4EMAPTCYP2C19POLBALDH1A1 | |
| SCHEMBL391979 | 0.81 | KDM4E (1.00) | KDM4EMAPTCYP2C19POLBALDH1A1 | |
| SCHEMBL20693656 | 0.81 | KDM4E (0.68) | KDM4EMAPTCYP2C19POLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11964967-B2 | Cardiac sarcomere inhibitors | CYTOKINETICS, INC. (US) | 2024-04-23 | — | — | US | disclosed |
| EP-3814342-B1 | CARDIAC SARCOMERE INHIBITORS | CYTOKINETICS INC (US) | 2022-07-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11964967-B2 | Cardiac sarcomere inhibitors | TNNI3, TNNT2, MYLK2 | KDM4E 2363/4885MAPT 2360/4885CYP2C19 3780/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.