Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.43 |
| ▸ | FGFR2 | P21802 | 4/20 | 0.43 |
| ▸ | FGFR3 | P22607 | 4/20 | 0.43 |
| ▸ | KDR | P35968 | 3/20 | 0.43 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 7/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 7/20 | 0.42 |
| ▸ | CDK1 | P06493 | 6/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 6/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 5/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL545872 | 1.00 | SMN1; SMN2 (0.44) | SMN1; SMN2ALDH1A1LMNAMAPTKCNJ1 | |
| SCHEMBL10240067 | 0.90 | L3MBTL1 (0.44) | MAPTFGFR1HDAC6CHEK1CDK7 | |
| SCHEMBL28507596 | 0.88 | FGFR1 (0.51) | SMN1; SMN2FGFR1FGFR2FGFR3KDR | |
| SCHEMBL30059177 | 0.88 | FGFR1 (0.51) | SMN1; SMN2FGFR1FGFR2FGFR3KDR | |
| SCHEMBL546253 | 0.84 | FGFR1 (0.45) | ALDH1A1MAPTFGFR1FGFR2FGFR3 | |
| SCHEMBL11888560 | 0.83 | FGFR1 (0.43) | FGFR1FGFR2FGFR3KDRPDPK1 | |
| SCHEMBL11037651 | 0.82 | PARP1 (0.52) | FGFR1FGFR2FGFR3KDRPDPK1 | |
| SCHEMBL12027286 | 0.81 | FGFR1 (0.45) | FGFR1FGFR2FGFR3KDRPDPK1 | |
| SCHEMBL12521833 | 0.81 | PDPK1 (0.43) | FGFR1FGFR2FGFR3KDRPDPK1 | |
| SCHEMBL27985423 | 0.80 | MAPT (0.44) | SMN1; SMN2ALDH1A1LMNAMAPTKCNJ1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112047932-B | Pyrazole spleen tyrosine kinase inhibitor and preparation method and application thereof | 中国药科大学 | 2022-11-08 | — | — | CN | disclosed |