Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.41 |
| ▸ | RXRB | P28702 | 1/20 | 0.41 |
| ▸ | RXRG | P48443 | 1/20 | 0.41 |
| ▸ | ATR | Q13535 | 3/20 | 0.39 |
| ▸ | CYP4F2 | P78329 | 5/20 | 0.37 |
| ▸ | CYP4A11 | Q02928 | 5/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | PDE9A | O76083 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 2/20 | 0.33 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.33 |
| ▸ | PDE1A | P54750 | 2/20 | 0.33 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.33 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19617703 | 1.00 | RXRA (0.41) | RXRARXRBRXRGATRCYP4F2 | |
| SCHEMBL5413171 | 0.86 | RXRA (0.40) | RXRARXRBRXRGATRCYP4F2 | |
| SCHEMBL25428423 | 0.85 | RXRA (0.39) | RXRARXRBRXRGATRCYP4F2 | |
| SCHEMBL23043131 | 0.85 | RXRA (0.39) | RXRARXRBRXRGATRCYP4F2 | |
| SCHEMBL19637212 | 0.84 | CYP4F2 (0.44) | RXRARXRBRXRGATRCYP4F2 | |
| SCHEMBL15266343 | 0.83 | RXRA (0.41) | RXRARXRBRXRGATRCYP4F2 | |
| SCHEMBL22499222 | 0.83 | RXRA (0.39) | RXRARXRBRXRGATRCYP4F2 | |
| SCHEMBL30483254 | 0.82 | ATR (0.42) | RXRARXRBRXRGATRCYP4F2 | |
| SCHEMBL28588706 | 0.82 | ATR (0.42) | RXRARXRBRXRGATRCYP4F2 | |
| SCHEMBL24968167 | 0.82 | RXRA (0.42) | RXRARXRBRXRGATRCYP4F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4087573-A1 | KRAS G12C INHIBITORS | Mirati Therapeutics, Inc. (US) | 2022-11-16 | — | — | EP | disclosed |