Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 6/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.36 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26647274 | 1.00 | MTOR (0.45) | MTORSMN1; SMN2KMT2AMAPTL3MBTL1 | |
| SCHEMBL26770859 | 0.87 | MTOR (0.43) | MTORSMN1; SMN2KMT2AMAPTL3MBTL1 | |
| SCHEMBL26647453 | 0.83 | MTOR (0.46) | MTORSMN1; SMN2KMT2AMAPTL3MBTL1 | |
| SCHEMBL30692457 | 0.81 | MTOR (0.43) | MTORSMN1; SMN2KMT2AMAPTL3MBTL1 | |
| SCHEMBL26646952 | 0.80 | MTOR (0.51) | MTORSMN1; SMN2MAPTL3MBTL1KCNQ3 | |
| SCHEMBL30068156 | 0.78 | MTOR (0.40) | MTORSMN1; SMN2KMT2AMAPTL3MBTL1 | |
| SCHEMBL26646921 | 0.78 | MTOR (0.40) | MTORSMN1; SMN2KMT2AMAPTL3MBTL1 | |
| SCHEMBL12463160 | 0.78 | SMN1; SMN2 (0.58) | MTORSMN1; SMN2KMT2AMAPTL3MBTL1 | |
| SCHEMBL30828952 | 0.76 | MTOR (0.48) | MTORSMN1; SMN2KMT2AMAPTL3MBTL1 | |
| SCHEMBL26646985 | 0.76 | MTOR (0.48) | MTORSMN1; SMN2KMT2AMAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4337198-A1 | POLO LIKE KINASE 4 INHIBITORS | Oric Pharmaceuticals, Inc. (US) | 2024-03-20 | — | — | EP | disclosed |
| WO-2022240876-A1 | POLO LIKE KINASE 4 INHIBITORS | ORIC PHARMACEUTICALS, INC. (US) | 2022-11-17 | — | — | WO | disclosed |